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Jump to: How common are headaches on Wegovy | Why Wegovy can cause headaches | Preventing and managing headaches | Eating well to reduce headache risk | Staying active | When to speak to your GP | Frequently asked questions | Take home message Headaches are a common side effect of Wegovy (semaglutide), affecting around 14% of people in clinical trials compared to 10% on placebo

And in the brain, the protein acts on the hypothalamus to suppress hunger

Clinical studies have shown that individuals using semaglutide experience a significant average weight loss of 14.9% within a year, with about one-third achieving an even more remarkable weight reduction exceeding 20% (PubMed)