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this finding suggests that the PI3K/ARAP3/(Ras homolog family member A (RhoA) signaling pathway plays a crucial role in Ex-4-mediated anti-inflammation [51]

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Note: animal studies indicate that high doses of DPP-4 inhibitors & GLP-1 agonists cause expansion of cells of the pancreatic ductal glands and can cause premalignant pancreatic intraepithelial lesions (PanIN) that have the potential to progress to pancreatic adenocarcinoma

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