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DPP-4 inhibitors were introduced for the treatment of type 2 diabetes in 2006

Semaglutide subcutaneous and dulaglutide reduced stroke cases
This article examines clinical safety data, GI mechanisms, and how genetic predispositions may influence medication tolerance in IBD patients see

Novo Nordisks Peter Johannsen, MD, highlighted the biological signals observed and acknowledged the clinical limitations: subgroup analyses did not reveal meaningful benefit, and any potential responder group would be very small