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In particular, the gutbrain axis has garnered attention as a bidirectional system capable of regulating mood, motivation, and reward-seeking behavior via endocrine, neural, and immune pathways [3,4]

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Both of these medications contain the inactive thyroid hormone T4 and in order for it to be active in your body, it must be converted to the active T3 thyroid hormone ( this process is known as T4 to T3 conversion )
