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I would also argue that estrogen hormone therapy, progesterone, testosterone, when indicated, is going to have a synergistic effect with these GLP ones

G.DamodaranS

In addition, it can also activate the UCP1 protein in brown adipose tissue (BAT), increase heat production, and achieve a transition from "energy wasting" metabolism (such as shivering heat production) to "efficient utilization" metabolism
In a STEP-1 extension analysis, participants regained a substantial portion of lost weight after stopping semaglutide (net loss was smaller by week 120)
