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Additionally, at the beginning of the study, the average participant weighed 214 pounds

This observation also highlights the complexity that modifying a residue within a cholesterol binding site might have on the overall pattern of receptor interactions with cholesterol and other plasma membrane lipids, as increased segregation to cholesterol-rich lipid rafts occurs despite an overall reduction in total cholesterol binding under vehicle conditions observed for the V229A mutant receptor

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As different classes of drugs target different aspects of T2DM via distinct mechanisms of action, a combination of treatments is generally more effective at maintaining glycaemic control than monotherapy over the long term [12]
