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DPP4-positive fibroblasts exhibit elevated expression of collagen-1, collagen-3, and fibronectin
In a phase 2 trial in participants with obesity and MASLD, once-weekly treatment with the GIP/GLP-1/GCG triple agonist retatrutide resulted in substantial reductions in liver fat, body weight, abdominal visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (ASAT), serum lipids

Pelvic floor physical therapy can be very effective in these cases, especially when standard treatments do not help

10.1177/1747493018778713 147 Sams-DoddF
