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Tirzepatide itself should be discontinued at least two months before planned pregnancy due to insufficient safety data

Perhaps even more compelling is the combination of ferroptosis inducers with immune checkpoint inhibitors, which has opened a new frontier for overcoming immunotherapy resistance in CRC, particularly in microsatellite stable (MSS) patients (150)

Retatrutide raises resting heart rate by around 6.7 bpm at 12 mg in the Phase 2 trial

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