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20 Our understanding suggests that drawing comparisons between different trials hints at a shared method of action

The widespread use of these drugs for weight loss has sparked debates as to the medicalisation of obesity and the ethics of using pharmaceuticals for body modification (Arillotta et al., 2023)

Eli Lilly says that Zepbound is a dual receptor agonist that targets both GIP and GLP-1 receptors, unlike other incretins approved for obesity management, which target only GLP-1 receptors. And Novo Nordisk says that Wegovy has the broadest GLP-1 label, including indications for reducing risk of major adverse cardiovascular events in some patients and for treatment of a certain liver condition in some adults

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