glp 1 gip dual agonist weight loss TrimRX Science Behind GLP 1 GIP

Both GIP and GLP-1 are rapidly metabolised after their secretion via the enzyme dipeptidyl peptidase (DPP-4)

Narayan KM, Boyle JP, Geiss MA, et al

Statement by an American Association of Clinical Endocrinologists/American College of Endocrinology consensus panel on type 2 diabetes mellitus: an algorithm for glycemic control 2009

However, given the uncertainty of the interruption interval of these medications, gastric ultrasound appears to be a crucial tool for identifying patients at high risk of pulmonary aspiration In summary, emerging evidence suggests that perioperative use of GLP-1RAs is associated with delayed gastric emptying and greater RGC, which in turn may increase the risk of pulmonary aspiration