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In DR, mitochondrial DNA leakage due to cellular stress or damage activates STING, which promotes inflammation and vascular dysfunction in retinal endothelial cells
In the GLP-1 RA group, 33 participants were subsequently newly diagnosed with heart failure, compared with 15 in the SGLT2i group (RR 0.44 [95% CI 0.23, 0.83] p =0.0092)
Beware of the rare possibility of serotonin syndrome with both these agents
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