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Description
The presence of GLP-1 receptors in testicular tissue and evidence of direct, weight-loss-independent effects on sperm function raises the possibility that GLP-1 drugs may act on male reproductive biology through two distinct mechanisms simultaneously: one systemic (through metabolic improvement) and one local (through direct testicular signaling)
Guidelines should outline criteria for patient selection, dosing regimens, monitoring parameters, and follow-up schedules
No lock-ins
Mounjaro acts on both GLP-1 and GIP receptors, while Wegovy contains semaglutide, which works on the GLP-1 pathway only
