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It may lose potency unpredictably
The review revisited SUSTAIN-6, where semaglutide-treated patients showed a hazard ratio of 1.76 for retinopathy complications compared with placebo. The discussion has since shifted toward whether rapid metabolic changerather than direct retinal toxicitymay explain the signal
2 (2023): 164175, 10.1093/cei/uxac115
Equally, an individual's experience may change after the switch
