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Growth in genital size could be a sign of a growth like a tumor or fluid accumulation

Meta-analyses have shown that the amount of weight regained after stopping treatment is typically proportional to the initial weight loss, and lifestyle interventions become increasingly difficult to maintain once the medication is discontinued (Berg et al., 2025)

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People will have to be on these drugs long-term or the weight will come back on, says Charlie Seltzer, MD , a board-certified obesity medicine doctor in Philadelphia