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dpp 4 inhibitors vs glp 1 agonist Mechanism of action for GIP, GLP-1 analogues and DPP4 in DPP-4 inhibitors and GLP-1RAs: cardiovascular
Description
Designing small molecules able to target multiple receptors might sound difficult, but Septerna says the allosteric binding site it has discovered is even better conserved across all incretin receptors than the site targeted by peptides and other small molecule drugs
Ma et al., 2020)
Its shorter duration of action produces pronounced effects on postprandial glucose through delayed gastric emptying
This can cause significant uncomfortable side effects like nausea, bloating, and constipation