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Key takeaway: GLP-1 RAs do not appear to increase pancreatitis risk, and may be associated with improved outcomes if pancreatitis occurs.

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In conclusion, this review indicates that the effects on HR differ within the class of GLP-1 RAs: short-acting GLP-1 RAs are associated with a modest and transient HR increase before returning to baseline levels, while some long-acting GLP-1 RAs are associated with a more pronounced and sustained increase during the day and night