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GLP-1 RAs, such as exenatide and lixisenatide, have shown benefits in addressing the pathology of PD in animal studies and phase II clinical trials, halting progression and delaying worsening of symptoms

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doi: 10.2337/diab.41.9.1042 38 DucaLMMaahsDMSchauerIEBergmanBCNadeauKJBjornstadPet al

Safety concerns were also raised in a phase 1 trial investigating the GLP-1R/GCGR agonist NNC9204-117, where a dose-dependent increase in heart rate was observed, in addition to increased markers of inflammation, hepatic disturbances, impaired glucose tolerance, and reduced blood levels of some amino acids despite clinically relevant weight loss (Friedrichsen et al