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Currently, the development of GLP-1RAs drugs continues to be unabated, with no apparent plateau in research or innovation

Yet, according to a set of intra-chain hydrogen bonding analysis of supplementary file 4452.pdb , it was found that two sets of hydrogen bond-like electrostatic interactions (Table 5) exist between the two positively charged side chains of Arg123 and Arg127, with donor-acceptor (D-A) distances at 3.23 and 3.19 and two ADH at 16.94 and 28.90, while a cutoff value of donor-acceptor (D-A) distance was defined as 3.0 [50], and a cutoff value of the angle formed by acceptor (A), donor (D) and hydrogen (H) ( ADH ) was defined as 30

Overall, the introduction of the new obesity pharmacotherapies may shift the focus of the multidisciplinary team on nutrition support during the rapid WL phase and on behavioural changes aiming to support long-term weight maintenance, similar to what is the focus after bariatric surgery
