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Absolute contraindications from the Zepbound label apply at any dose: Personal or family history of medullary thyroid carcinoma or MEN-2 syndrome Prior serious hypersensitivity reaction to tirzepatide Active pancreatitis or significantly elevated pancreatitis risk Severe gastroparesis (tirzepatide slows gastric emptying further) Type 1 diabetes Current or planned pregnancy within 1 month History of suicidal ideation per the Zepbound label warning Goal-fit contraindications are the part competitors skip

Policy But when it comes to the different types of GLP-1s, like tirzepatide vs

doi: 10.1016/S2213-8587(24)00377-2

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