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JAMA Oncol

Effect sizes differences were medium to large

GLP1s reduce appetite and cravings because these medications: Promote satiety after smaller meals Slow down how quickly the stomach empties Alter the brains response to food rewards These physiological effects create the foundation for improved eating behavior managementespecially when integrated with lifestyle support

According to the STEP clinical trials referenced in NICE TA875, patients treated with Wegovy achieved substantial weight loss, typically in the range of 10-15% of initial body weight over 68 weeks of treatment when combined with lifestyle interventions