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The regulatory landscape creates another significant distinction

Multisite regulation of insulin secretion by cAMPincreasing agonists: Evidence that glucagonlike peptide 1 and glucagon act via distinct receptors

Phentermine, the stimulant component of Qsymia, can increase heart rate and is generally avoided in patients with significant cardiovascular disease

Those with a personal or family history of medullary thyroid cancer, multiple endocrine neoplasia syndrome type 2, or previous episodes of pancreatitis need thorough medical evaluation before starting treatment
