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As this study showed comparable exposures between the 1G and 2G formulations of oral semaglutide that met stringent regulatory bioequivalence criteria, it is considered unlikely that there will be any clinically meaningful differences in efficacy or safety between these formulations

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(4) decrease in enterocyte chylomicron production and secretion responsible for direct transport of triglycerides to the liver

Minireview: Finding the sweet spot: Peripheral versus central glucagon-like peptide 1 action in feeding and glucose homeostasis