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A recent analysis of FDA adverse event reporting system (FAERS) data from 2004 to 2020 revealed a notable association between GLP-1 RAs and malignant pancreatic neoplasms (proportional reporting ratio [PRR], 9.86) [52]
Primary Handling Editor: Ming Yang, in collaboration with the Nature Medicine team
The highly conserved master regulator of several metabolic pathways, AMPK, may be useful in treating obesity, non-alcoholic fatty liver disease and T2D [63]
"The oral format could broaden adoption because many patients and physicians are more comfortable with pills than injections," explained Dr
