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Originally developed to manage type 2 diabetes, these medications mimic the GLP-1 hormone, which plays a key role in regulating appetite, slowing gastric emptying, and enhancing feelings of fullness

If antiemetics are prescribed, the GI AEs should be monitored and, if they have not reduced once the course of antiemetics is complete, the patient should be switched from the GLP1RA to another glucoselowering therapy

National Institute of Health (NIH), after analyzing weights and cardiovascular, metabolic risk factors a year after suspending the Wegovy treatment, patients regained two-thirds of the lost weight on average, and their cardiovascular, metabolic risk factors also returned to similar levels to changed weights

The second mechanism is characterized by the modulation of intracellular calcium, which seems to function as a trigger for rapid insulin exocytosis and complements the amplification phenomena [8]