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This Review profiles established and emerging GLP-1-based medicines, discussing optimization of pharmacokinetics and tolerability, engagement of new therapeutically useful pathways and safety aspects

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however, none objected

Proinflammatory mediators such as interleukin-6 (IL-6), interleukin-1 (IL-1), and LPS have also been reported to directly stimulate GLP-1 secretion from intestinal endocrine L cells