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However, as polypeptide drugs, GLP-1RAs are easily hydrolyzed by enzymes in the gastrointestinal environment

A 2023 retrospective cohort analysis in JAMA Internal Medicine (N=16,922) found that patients on a GLP-1 RA plus an opioid had a 33% higher rate of bowel obstruction-related ED visits compared to patients on a GLP-1 RA alone [5]

In a landmark development, liraglutide (Saxenda) was approved in 2020 for use in adolescents aged 12-17 years with a body weight above 60 kg and an initial BMI corresponding to 30 kg/m for adults [17]

The authors speculate that the residue-free diet prescribed to patients for bowel preparation prior to colonoscopy might have played a role [16]