glp-1 gip mechanism of action glp-1_analogs [TUSOM Mechanism of action of GLP-1

Cogen AL, Desai K, Elder D, et al

Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) in the mouse: relationships between monoamine oxidase, MPTP metabolism and neurotoxicity

Key supplements for anyone on GLP-1 therapy include a high-quality multivitamin, vitamin B12 (especially important since some compounded formulations include B12 for this reason), vitamin D, and a fiber supplement if constipation is an issue

These effects were abolished by GLP-1R siRNA treatment, further demonstrating that GLP-1R may exert a protective effect in chondrocytes against ER-associated apoptosis in OA