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A major contributor was prescription drug spending, which rose 9.4% in 2025, driven in part by growing use of GLP-1 medications, some of which have list prices exceeding $1,000 per month, according to various estimates
Cumulative receptor engagement and therefore weight loss is determined by total weekly dose, not peak height

Kim T, Nason S, Holleman C et al (2018) Glucagon receptor signaling regulates energy metabolism via hepatic Farnesoid X Receptor and fibroblast growth factor 21

Fat is stored energy, says family medicine physician David Brill, DO
