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Combining semaglutide and phentermine is sometimes considered for weight management, but this dual-agent approach carries specific safety and efficacy considerations that require medical evaluation

Key Points Question What effect does continued treatment with 2.4 mg of subcutaneous semaglutide have on the maintenance of body weight loss in adults with overweight or obesity without diabetes

Research Applications of Retatrutide Triple receptor agonism studies, comparing GCGR, GLP-1R, and GIPR activation profiles in cell-based reporter assays against single-agonist semaglutide and dual-agonist tirzepatide reference standards