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The FDA removed tirzepatide from the drug shortage list in December 2024 and semaglutide in February 2025, eliminating the primary legal basis for "essentially a copy" compounding of these substances

Additionally, guidelines from the American Diabetes Association provide evidence-based recommendations for GLP-1 use

Tier 2 and Tier 3 weight management services provide intensive support Dietetic input : Specialist dietitians can develop individualised plans accommodating Crohn's-related dietary restrictions whilst achieving caloric deficit Psychological support : Cognitive behavioural therapy and motivational interviewing address eating behaviours and emotional factors Physical activity programmes : Tailored exercise plans considering Crohn's-related fatigue and extra-intestinal manifestations Bariatric surgery represents the most effective long-term weight management intervention for severe obesity

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