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Semaglutide injections are administered once weekly into subcutaneous fat (usually the abdomen, thigh, or upper arm), which contains abundant small blood vessels

Semaglutide's extended half-life (approximately 7 days) means the medication accumulates in the bloodstream with each weekly injection, creating prolonged effects on blood pressure and fluid balance compared to shorter-acting GLP-1 agonists

Following the use of GLP-1 agonists, patients may also present with symptoms warranting further targeted imaging evaluation

Sometimes doctors may choose to inject Botox into the muscle to paralyze it for a few months which is a simpler procedure but only lasting a limited time.