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Targeting the incretin/glucagon system with agonists Figure 1: Schematic representation of the effects of multi-agonists targeting the receptors for GLP-1/Glucagon, GLP-1/GIP and GLP-1/GIP/Glucagon [28] In Part I of our blog we reported on dual receptor agonists targeting the incretin/glucagon system to treat obesity and type 2 diabetes mellitus with high efficacy

The diabetes prevention and reversal potential of these medications may ultimately prove more significant than their weight loss effects

This evidence supports the model that GLP-1 medications work best as ongoing therapies rather than short-term interventions

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