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however, some discontinuations were actually due to "perceived excessive weight loss," highlighting the potency of the drug

EFFECT OF GUT MICROBIOTA ON GLP-1 RHYTHM Circadian rhythms refer to physiological changes in an organisms activities that occur almost every 24 hours, also known as the biological clock (118)

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GLP-1 receptor agonists have become a paradigm shift in treating the two conditions together, and clinical trials have shown an average of 15-22% body weight loss with recent preparations (semaglutide and tirzepatide)
