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2, 21 These species differences were confirmed by Bjerre-Knudsen et al 15 and Boess et al

Risk factors for the development of cardiotoxicity are thought to be pre-existing cardiovascular disease, older age, female sex, longer duration of therapy, and renal impairment
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2 Chronic kidney disease poses a significant risk of kidney failure, cardiovascular events and death, 3 highlighting the critical need for research into its prevention and treatment