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An allergic skin reaction can be triggered by many substances or conditions, including medicines (pain killers or antibiotics), foods (egg, shellfish, and peanut), illicit drugs or alcohol, bacterial or viral infections, blood transfusion, insect bites, pollens, pet dander, emotional distress, hot or cold climate, sunlight, scratching, or exercise

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Treatment typically begins with a 0.25 mg weekly dose for four weeks as a starter dose for tolerability only, then increases to 0.5 mg once weekly for glycaemic control