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PD-1 knockout CAR-T therapy Knocking out the PD-1 gene in CAR-T cells can significantly enhance T cell immune activity, thereby improving the clinical efficacy of CAR-T therapy in antitumor treatment (Figure 4D)

For instance, bariatric surgery has demonstrated significant long-term benefits for MASH patients, with notable improvements in histological MASH and fibrosis observed five years post-operation [24]

More generally, the prevalence of T2DM in adults with PWS ranges from 11 to 25%, compared to 5 to 7% in the general population (189), while it is reported less than 2% in patients younger than 18 years of age (190)

Side Effects: Common Side Effects 1