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The most important approach is gradual dose titration : starting with the lowest available dose and increasing slowly according to the manufacturer's recommended schedule allows the gastrointestinal system time to adapt

More serious but less common risks include pancreatitis, gallbladder disease, acute kidney injury (particularly in the setting of dehydration from gastrointestinal symptoms), and hypoglycemia when used in combination with insulin or insulin secretagogues

Anavar may slightly elevate blood pressure in some users

Cardiovascular outcomes requirement: FDA might require cardiovascular outcomes trial data before approval, which could add 2-3 years