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All DPP4i are more selective for DPP4 compared to other enzymes in the same family, such as FAP, DPP8, and DPP9, with selectivity ranging from less than 100fold for vildagliptin and saxagliptin to more than 14 000fold for alogliptin [66]

The original Indiana University filings that underpin the DiMarchi peptide chemistry remain a distinct estate (39 publications, 7 families) that Lilly has historically been the principal exclusive licensee of

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