Why Weight Loss Plateaus on Tirzepatide
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Description
Patients inject the medication into fatty tissue, typically in the abdomen, thigh, or upper arm
Tirzepatide produces more weight loss than semaglutide, averaging 20 to 24% body weight reduction compared to semaglutide at approximately 15%
Common Ozempic side effects are most pronounced for the first two to six weeks of taking semaglutide
Cardiovascular Outcomes# EXSCEL Trial (Exenatide)# The EXSCEL trial (Holman et al., NEJM 2017) enrolled 14,752 patients with T2D (73.1% with prior CV disease): Primary MACE: HR 0.91 (95% CI 0.83-1.00, p=0.06 for superiority) Non-inferiority achieved
