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Without automatic substitution authority, the biosimilar company must deploy a commercial team equivalent in scale to a branded drug launch to specifically drive prescribers toward its product a cost structure that fundamentally undermines the low-price, high-volume generic business model

Interest in the drugs has expanded beyond metabolic disease as researchers have begun exploring their broader biological effects

GLP-1RAs are known to delay gastric emptying a condition in which the stomach empties slower than normal potentially leading to the presence of residual gastric content (RGC) in appropriately fasted patients

Also, higher-protein diets have been shown to help conserve muscle mass during periods of energy restriction