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(1) intravenous administration with EMPA (10 mg/kg, Adipogen life sciences, Liestal, Switzerland) followed by administration with PBS an hour after the administration with EMPA, (2) intravenous administration with LINA (10 mg/kg, Adipogen life sciences, Liestal, Switzerland) followed by administration with PBS at an hour, (3) concurrent administration with EMPA (10 mg/kg) and LINA (10 mg/kg) followed by administration with PBS at an hour, and (4) intravenous administration with EMPA followed by administration with LINA at an hour (10 mg/kg)