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Holubov M, Hrub L, Popelov A, Bencze M, Praienkov V, Gengler S, et al
Numerous studies have documented a high prevalence of IR in individuals with major depressive disorder and bipolar disorder, even in the absence of obesity or overt metabolic disease [36,37]
Sublingual delivery bypasses first-pass liver metabolism, potentially improving bioavailability compared to swallowed oral forms, though it still does not match injectable absorption rates
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