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It is found that in the clinical follow-up studies of NAFLD patients, compared with the control group, hepatic fat content and ALT levels were not significantly reduced in Lira group and were associated with an increased incidence of gastrointestinal adverse events [118]

One study showed that the introduction of liraglutide increased AMPK phosphorylation and reduced phospho-IKK/ S176/S180, phospho-NF-B p65, phospho-JAK2, phospho-STAT3, SOCS3, TNF-, and IL-6 levels

Many patients notice changes in appetite within weeks, but significant weight loss usually develops gradually over several months

Call your doctor if the nausea is extreme or is not fading as time passes
