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Dermal Hypersensitivity Reaction to Semaglutide: Two Case Reports Semaglutide is a glucagon-like peptide-1 (GLP-1) analog that was FDA-approved in 2017 for treatment of type II diabetes and in 2021 for treatment for chronic weight management in adults with obesity or overweight with at least one weight-related condition.1 Due to its longer duration of action, it is typically administered subcutaneously once weekly

The absence of strong clinical evidence validating the safety of microdosing underscores the importance of cautious, evidence-based approaches to medication management

Rapid weight loss, particularly when exceeding 1.5 kg (3.3 pounds) per week, promotes cholesterol supersaturation in bile and crystal formation

For those managing thyroid-related health concerns, including a history of thyroid cancer, understanding how semaglutide interacts with overall thyroid health is essential