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Population and endpoints A definitive trial would enroll patients with biopsy-confirmed MASH and clinically meaningful fibrosis typically stage F2F3, the range where progression risk and regulatory interest are highest and would be powered against the two histologic endpoints regulators recognize: resolution of steatohepatitis without worsening of fibrosis, and improvement in fibrosis by at least one stage without worsening of steatohepatitis

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doi: 10.1007/s00125-018-4663-6 19 TanSATanL

Dysgeusia can result from numerous other causes, including dental disease, oral infections, vitamin deficiencies (particularly zinc and vitamin B12), other medications (such as metronidazole, ACE inhibitors, and certain antibiotics), and systemic conditions such as poorly controlled diabetes itself