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Adequate hydration, moderate fat intake (very low-fat diets paradoxically increase gallstone risk by reducing gallbladder contractility), and ursodiol prophylaxis for patients with known gallbladder disease risk factors may reduce this concern

Split-dosing (taking a weekly dose in two or more smaller sub-weekly injections) changes the trough-to-peak ratio and can soften side effects at higher dose levels

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Future studies should continue to explore the dual mechanism of action of GLP-1R in metabolism and the nervous system, especially its potential applications at the intersection of AD and DM