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A NEW large-scale cohort study suggests that glucagon-like peptide-1 receptor agonists (GLP-1 RAs), widely prescribed for diabetes and obesity, may significantly increase the risk of neovascular age-related macular degeneration (nAMD) in older adults with diabetes

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Jimenez S, Torres M, Vizuete M, Sanchez-Varo R, Sanchez-Mejias E, Trujillo-Estrada L, Carmona-Cuenca I, Caballero C et al (2011) Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer mouse model