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doi: 10.1016/j.biomaterials.2019.119491 [DOI] [PMC free article] [PubMed] [Google Scholar]

The Wegovy SmPC advises that semaglutide should be discontinued if pancreatitis is suspected Signs of gallbladder disease including right upper quadrant pain, fever, or jaundice, as GLP-1 receptor agonists and weight loss can increase the risk of gallstones Routine GP consultation is advisable for: Gastrointestinal symptoms persisting beyond 46 weeks without improvement Symptoms significantly impacting quality of life or nutritional intake Unexplained weight loss exceeding expected therapeutic effects New onset of symptoms differing from initial side effects Concerns about symptom severity or medication tolerability NICE guidance on obesity management (TA875) emphasises the importance of regular monitoring during pharmacological weight management interventions

Critics also highlight that brand-name GLP-1 manufacturers have secured extensive patent protection, averaging 19.5 patents per drug and 18.3 years of expected exclusivity, with over half of these patents focused on delivery devices rather than the drugs themselves [71]