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We also describe the development of incretin-based pharmacotherapy, starting with exendin- 4 and ending with the identification of multi-incretin hormone receptor agonists, which appear to be the next major step in the fight against T2DM and obesity

Much anticipated Phase II results in obesity for Amgens GLP-1 agonist/GIP antagonist showed up to 20% weight loss, but without detailed data the drugs competitiveness is hard to ascertain.

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