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This Review summarizes the available data about combination immunotherapies in T1DM, particularly addressing their clinical importance.

Benefits: Glycemic control: Tirzepatide helps lower blood sugar levels by increasing insulin secretion and reducing glucagon production

Although glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are highly effective for body weight reduction, there remains a critical unmet need for complementary strategies that drive selective fat loss and sustain long-term weight reduction

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